所在学科专业：

病理学与病理生理学

研究方向：

一直从事将基因工程化噬菌体纳米生物材料应用于肿瘤治疗、肿瘤检测、生物矿化和干细胞诱导分化等研究。近五年，在Nature Nanotechnology, Advanced Materials等国际主流期刊发表噬菌体领域SCI论文17篇（含中科院一区论文8篇），累计引用700余次。研究工作被Science、Nature Reviews Bioengineering、Nature Protocols、Science Advances、Chemical Reviews、Chemical Society Reviews等学科顶级期刊正面他引。应聘人获中国发明专利授权2项、美国发明专利授权1项。加入吉林大学基础医学院后，本课题组将开展如下研究：

1.基于噬菌体展示与人工智能的高特异性亲和肽发现（如蛋白质受体、纳米颗粒、肿瘤和生理性屏障等）；

2.工程化噬菌体和病毒颗粒介导的肿瘤精准治疗（如饥饿治疗、免疫治疗、光动力/光热治疗等）；

3.基于工程化噬菌体的肿瘤疫苗研发；

4.工程化噬菌体在干细胞定向分化中的应用；

5.人工智能联合合成生物学研究耐药菌治疗；

讲授课程：

本科生：《形态学研究方法》、《生物医学科学综合实践》

研究生：《形态学研究方法》

教育经历：

2015.01-2017.01：University of Oklahoma|生物化学|联合培养博士（导师：毛传斌）

2011.09-2017.07：东北师范大学|细胞生物学|博士（导师：毛传斌/王丽）

2007.09-2011.06：吉林大学|生物技术|学士

工作经历：

2026.02-至今：吉林大学|基础医学学院|副教授

2023.10-2026.02：浙江大学医学院附属第二医院|生物纳米医学|特聘研究员

2022.08-2023.10：杭州融华再生医学科技有限公司|研发部|实验室研究员

2020.05-2022.04：浙江大学|生物纳米医学|助理研究员

2017.09-2020.02：University of Oklahoma|纳米医学|博士后/助理研究员

科研项目：

1.吉林省卫生健康科技能力提升计划一般探索类项目A类（2026WS-YA004），基于工程化噬菌体的三阴性乳腺癌靶向治疗及机制研究，2026.7-2028.8，负责人。（30万）

2.国家自然科学基金青年基金（82202303）。基于双展示工程噬菌体fd388-BH-WV应用于三阴性乳腺癌脑转移瘤的靶向“饥饿”治疗，浙江大学，2023-01-01至2025-12-31，负责人。（30万）

3.浙大二院青年科研人员种子基金，基于工程化噬菌体的口腔鳞状细胞癌靶向联合治疗，2024年10月至2026年10月，负责人。（10万）

4. NSF EPMD-ElectrnPhoton&MagnDevices (1917037), Plasmonically-Induced Phase-Correlated Ultralong Transport of Excitation Energy in Viral Quantum Dot Circuits. The University of Oklahoma, 2019-09-01至2023-08-31，主要参与人。(329,376美元)

5. NIH NIBIB (5R01EB021339), Virus-based Nanoparticles for Detecting Breast Cancer Biomarkers, The University of Oklahoma, 2016-05-01至2020-02-29，主要参与人。(338,406美元)

6. NIH NCI (7R21CA195607)，Hiring Non-toxic Virus Nanoparticles to Count Cancer Biomarker Molecules，The University of Oklahoma, 2015-09/01至2018-08-31，主要参与人。(195,175美元)

7. NIH NCI (1R21CA200504)，Selective Tumor Inhibition by Tumor-homing Angiogenesis-suppressing Nanofibers NIH，The University of Oklahoma, 2015-09-01至2016-08-31，主要参与人。(164,432美元)。

8. NSF BIOSENS-Biosensing (1512664), Translation of Nano-biorecognition into Macroscopic Counting for Attomolar Detection of Biomolecules，The University of Oklahoma, 2015-05-26至2019-08-31，主要参与人。(300,000美元)

9.吉林省科学技术厅项目 (20130727034YY)。基于p53抗体的肿瘤筛查生物诊断试剂开发，东北师范大学，2013-07-01至2016-06-30，参与人。（80万）

10.吉林省科学技术厅项目（20130206009YY）。基于噬菌体展示技术的甲状腺癌诊断试剂，东北师范大学，2013-01-01至2015-12-31，参与人。（14万）

学术论文：

1.Xu, S.; Liang, P.; Zhong, L.; Fu, X.*,Li, Y.*; Wang, Y.*; Nanomaterials in Oral Regeneration: Current Advances and Future Directions. Regenerative Medicine and Dentistry 2025, 2(4): 16. (共同通讯)

2.Yue, H.;Li, Y.; Yang, T.; Wang, Y.; Bao, Q.; Xu, Y.; Liu, X.; Miao, Y.; Yang, M.; Mao, C.*; Filamentous Phages as Tumour-Targeting Immunotherapeutic Bionanofibres,Nature Nanotechnology, 2025, 20(1): 167-176. (IF=34.9，中科院1区)

3.Yang, Y.; Xu, C.; Xu, S.;Li, Y.; Chen, K.e.; Yang, T.; Bao, J.; Xu, Y.; Chen, J.; Mao, C.*; Chen, L.*; Sun, W.*; Injectable Hydrogels Activated with Copper Sulfide Nanoparticles for Enhancing Spatiotemporal Sterilization and Osteogenesis in Periodontal Therapy,Biomaterials Science, 2025, 13(6): 1434-1448. (IF=5.7，中科院3区)

4.Li, H.-D.; Chen, Y.-Q.;Li, Y.; Wei, X.; Wang, S.-Y.; Cao, Y.; Wang, R.; Wang, C.; Li, J.-Y.; Li, J.-Y.*; Ding, H.-M.*; Yang, T.*; Wang, J.-H.; Mao, C.*; Harnessing Virus Flexibility to Selectively Capture and Profile Rare Circulating Target Cells for Precise Cancer Subtyping,Nature Communications, 2024, 15(1): 5849. (IF=14.7，中科院1区)

5.Bao, Q.; Liu, X.;Li, Y.;Yang, T.; Yue, H.; Yang, M.*; Mao, C.*; Development of Magnetic Nanoparticles with Double Silica Shells of Different Porosities for Efficient siRNA Delivery to Breast Cancer Cells,Materials Advances, 2024, 5(4): 1626-1630. (IF=5.2，中科院4区)

6.Li, Y.; Bao, Q.; Yang, S.*; Yang, M.*; Mao, C.*; Bionanoparticles in Cancer Imaging, Diagnosis, and Treatment,VIEW, 2022, 3(4): 20200027. (IF=9.7,中科院3区，Top 10 most-cited papers)

7.Li, Y.; Cao, B.; Modali, S.; Lee, E.M.Y.; Xu, H.; Petrenko, V.; Gray, J.J.; Yang, M.*; Mao, C.*; Understanding the Interactions between Bone Mineral Crystals and Their Binding Peptides Derived from Filamentous Phage,Materials Today Advances, 2022, 15: 100263. (IF=10，中科院2区)

8.Jiang, H.^1§;Li, Y.^1§; Cosnier, S.; Yang, M.*; Sun, W.*; Mao, C.*; Exploring Phage Engineering to Advance Nanobiotechnology,Materials Today Nano, 2022, 19: 100229. (IF=10.3，中科院1区)

9.Zeng, Y.; Yue, H.; Cao, B.;Li, Y.; Yang, M.*; Mao, C.*; Target-Triggered Formation of Artificial Enzymes on Filamentous Phage for Ultrasensitive Direct Detection of Circulating Mirna Biomarkers in Clinical Samples,Angewandte Chemie International Edition, 2022, 61(45): e202210121. (IF=16.6，中科院1区)

10.Yue, H.;Li, Y.; Yang, M.*; Mao, C.*; T7 Phage as an Emerging Nanobiomaterial with Genetically Tunable Target Specificity,Advanced Science, 2022, 9(4): 2103645. (IF=15.1，中科院1区)

11.Wan, Y.; Zong, C.; Li, X.; Wang, A.;Li, Y.; Yang, T.; Bao, Q.; Dubow, M.; Yang, M.*; Rodrigo, L.-A.*; Mao, C.*; New Insights for Biosensing: Lessons from Microbial Defense Systems,Chemical Reviews, 2022, 122(9): 8126–8180. (IF=62.1，中科院1区)

12.Wu, X.;Li, Y.; Yang, M.*; Mao, C.*; Simultaneous Ultrasensitive Detection of Two Breast Cancer Microrna Biomarkers by Using a Dual Nanoparticle/Nanosheet Fluorescence Resonance Energy Transfer Sensor,Materials Today Advances, 2021, 12: 100163. (IF=7.579，中科院2区)

13.Zhang, X.; Dong, S.; Huang, Y.; Shi, H.; Chen, X.; Wang, Y.;Li, Y.;Cao, D.*; Wang, L.*; A Scfv Phage Targeting the C. Albicans Cell Wall Screened from a Bacteriophage-Based Library of Induced Immune Protection in Mice,Infection, Genetics and Evolution, 2022, 102: 105303. (IF=3.2，中科院4区)

14.Qiu, P.; Wang, L.;Li, Y.; Mao, C.*; Weak Electrostatic Interaction Enabled Highly Oriented Assembly of Gold Nanorods onto Ultrathin Flagella Bionanofibers,Small Structures, 2021, 2(7): 2000121. (IF=10.343，中科院2区)

15.Wang, L.; Qiu, P.; Yang, T.; Zhou, N.; Zhai, M.;Li, Y.; Zhou, Y.; Zou, S.; Yang, M.*; Mao, C.*; 3d Bacterial Flagella as Both Synthetic Biotemplates and Ultrathin Spacers for Enhanced Inter-Particle Coupling and Solar Energy Harvesting,Materials Horizons, 2021, 8(7): 2097-2105. (IF=15.717，中科院1区)

16.Wang, L.; Qiu, P.;Li, Y.;Zhou, N.; Yang, M.; Mao, C.*; Polyethyleneimine-Enabled Tunable Electrostatic Nanoparticle Assemblies on Ultrathin Protein Nanofibers for Plasmonics-Based Solar Energy Harvesting,ACS Applied Nano Materials, 2021, 5(1): 832-839. (IF=6.14，中科院3区)

17.Li, Y.; Qu, X.; Cao, B.; Yang, T.; Bao, Q.; Yue, H.; Zhang, L.; Zhang, G.; Wang, L.; Qiu, P.; Zhou, N.; Yang, M.*; Mao, C.*; Selectively Suppressing Tumor Angiogenesis for Targeted Breast Cancer Therapy by Genetically Engineered Phage,Advanced Materials, 2020, 32(29): e2001260. (IF=30.849，中科院1区，封面论文)

18.Xu, H, Cao, B,Li, Y, Mao, C.*; Phage Nanofibers in Nanomedicine: Biopanning for Early Diagnosis, Targeted Therapy, and Proteomics Analysis,Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2020, 12(4): e1623. (IF=9.182，中科院2区)

19.Zhou, N.;Li, Y.; Loveland, C.H.; Wilson, M.J.; Cao, B.; Qiu, P.; Yang, M.*; Mao, C.*; Hierarchical Ordered Assembly of Genetically Modifiable Viruses into Nanoridge-in-Microridge Structures,Advanced Materials, 2019, 31(52): e1905577. (IF=27.398，中科院1区)

20.Cao, B.;Li, Y.; Yang, T.; Bao, Q.; Yang, M.*; Mao, C.*; Bacteriophage-Based Biomaterials for Tissue Regeneration,Advanced Drug Delivery Reviews, 2019, 145: 73-95. (IF=13.3，中科院1区)

21.Yang, M.^1§;Li, Y.^1§; Huai, Y.; Wang, C.; Yi, W.; Mao, C.*; Evolutionary Selection of Personalized Melanoma Cell/Tissue Dual-Homing Peptides for Guiding Bionanofibers to Malignant Tumors,Chemical Communications, 2018, 54(13): 1631-1634. (IF=6.163，中科院2区)

22.Wang, Y.; Shi, H.; Dong, S.;Li, Y.; Wang, M.; Huai, Y.; Zhang, X.; Chen, X.; Mao, C.; Gao, X.*, Wang, L.*; Nontoxic Engineered Virus Nanofibers as an Efficient Agent for the Prevention and Detection of Fungal Infection,Nano Research, 2018, 11(4): 2248-2255. (IF=8.515，中科院1区)

23.Li, Y.; Cao, B.; Yang, M.; Zhu, Y.; Suh, J.; Mao, C.*; Identification of Novel Short BaTiO₃-Binding/Nucleating Peptides for Phage-Templated in Situ Synthesis of BaTiO₃Polycrystalline Nanowires at Room Temperature,ACS Applied Materials & Interfaces, 2016, 8(45): 30714-30721. (IF=8.097，中科院2区)

24.Dong, S.; Shi, H.; Cao, D.; Wang, Y.; Zhang, X.;Li, Y.; Gao, X.*; Wang, L.*; Novel Nanoscale Bacteriophage-Based Single-Domain Antibodies for the Therapy of Systemic Infection Caused by Candida Albicans,Scientific Reports, 2016, 6: 32256. (IF=4.122,中科院3区)

科研获奖：

教改项目：

教改论文：

著作教材：

获奖情况：

专利：

1.Chuanbin Mao;Yan Li; Anti-angiogenin Peptides, Compositions, and Methods of Use, 2023-12-12,美国, US16/623,684

2.毛传斌;李龑;杨明英.一种羟基磷灰石靶向肽及用途. 2022-06-10.中国ZL 2022 1 0660345.4.

3.孙伟莲;杨涛;李龑;杨玉婷;包佳琦;张海正;陈莉丽.一种原位固化抗菌骨损伤修复凝胶及其制备方法. 2021-01-28.中国ZL 2021 1 0119373.0.

社会兼职：

中国生物工程学会噬菌体技术专业委员会委员

中华医学会病理学分会青年委员

BMEMat青年编委、iMeta青年编委、Intelligent Oncology青年编委、Regenerative Medicine and Dentistry青年编委